Scientists Unveil Biological Signatures in Worst Case


Although the parameters are not always determined, the responses of the immune system to disease can be divided into three categories: type 1, which injects certain viruses and bacteria into our cells; Type 2, which fights parasites such as worms that do not invade cells; and type 3, following fungi and bacteria that can live outside the cells. Each branch uses different cytokines to stimulate different types of molecular fighters.

People with moderate cases of & # 39; Covid-19 & # 39; takes what appears to be the most plausible form, focusing on answers of type 1, the Iwasaki team found. Patients who are struggling to recover, on the other hand, tend to inject an extraordinary number of types 2 and 3 responses, which are a “loose,” type. Iwasaki said. "As far as we know, there is no humiliation involved."

Itâ & # x20AC; & # x2122; s like the defensive system is struggling & # 39; Dr. Wherry said.

This distinction also seems to extend to the control of B cells and T cells – two types of defense fighters that always need to negotiate to organize their attacks. Certain types of T cells, for example, are important for the synthesis of B cells in the production of immune cells.

Last month, Drs. Wherry and colleagues published a paper on scientific findings that, in many patients with severe Covid-19, the virus somehow led to the separation of the two cohesive communities. It's too early to tell for sure, but maybe something about the coronavirus prevents cells B and T from "talking to each other," he said.

These studies suggest that treatment of adverse cases of Covid-19 may require the restoration of immunity – as a drug, which can restore the body's balance and revitalize the communication lines of bamboozled cells. This type of treatment may even focus on a part of the patient's body that has a severe reaction to the virus, Drs. Blish said: "Those who have already released cytokines."

But that is as easy as it sounds. "The challenge here is trying to slow down the response, without completely controlling it, and getting the right answers," he said. August said. It is difficult to fix that.

Time is also important. Make an early patient with irritable immune symptoms, who may not respond strongly; Give it a long time, and the worst damage may have already been done. The same is true of treatments designed to supplement the initial response to coronavirus infection, such as interferon-based treatment, Drs. Blish said. These can eliminate the & # 39; pathogen & # 39; if given shortly after infection – or they are badly removed from the body if administered for too long a delay.