Thierry Henry is still waiting for his first win since the Monaco coach after his side's defeat in last week's 1-0 league defeat looga Reims.
Mathieu Cafaro, who scored 24 minutes from Mathieu Cafaro, gave the three points to Henry and left the club without a win in four games following Monaco's appointment.
The two teams have completed 10 players with Alaixys Romao given a free transfer to Youssef Ait Bennasser, before Monaco saw Guinea-Bissau star Pele having picked up two red cards.
"It's not about tomatoes tonight, and I do not want it here," said Henry. "Reims won the attack on the pitch and when you did not win, you can not win at any level or league."
Monaco, who won the French league in 2017, remain the second team after a dramatic defeat to just one win in all competitions this season.
They will lower their feet on the table if Guingamp, who is unbeaten in his last five league games, avoid losing to Nantes on Sunday.
"It is worrying about the defeat to Strasbourg," added Henry, who recalled his side's 2-1 loss in the first leg of last month.
"There are a lot of players, lots of chances and lots of lost players, we have won 11 games in just 10 games, but then we'll have a red card."
Henry will now quickly change his focus on Monaco in the Champions League next season, with the highest chance of reaching the next round when they host Club Brugge on Tuesday.
Lyon captain Nabil Fekir has started his last game for a month with an ankle injury in the 1-1 draw with Bordeaux.
Houssem Aouar, who played for the right-back Fekir, gave Lyon the lead, but Bordeaux had a point in the 73rd minute with Andreas Cornelius equalizing in the 73rd minute.
Nimes have won nine successive unbeaten games with a 4-0 win over Dijon, while Patrick Vieira Nice beat the Amiens 1-0 after a goal by Prince-Griano.
Strasbourg missed five games without defeat after a 1-1 draw with Toulouse, Senegal winger Ismail Sarr has netted Rennes in the 2-1 win over Caen.
Montpellier sit second if they beat Marseille on Sunday, following Paris Saint-Germain 11 points clear of a 2-1 win over Lille.
Kylian Mbappe and Neymar scored against Parc des Princes on Friday, as the French champions started well this season with a 12-match win over Ligue 1.